Judith Pool discovers a simple way to make cryoprecipitates (cold insoluble precipitates that contain factor VIII) for the treatment of hemophilia

A great advancement came in the mid-1960s with the discovery of a method for preparing factor VIII from FFP by allowing it to thaw in the cold (cryoprecipitated plasma). This preparation could be stored in frozen form as “cryoprecipitate.” This allowed intravenous administration of more factor VIII in a smaller volume, allowing outpatient treatment for bleeds and even elective surgery in persons with hemophilia A.This more concentrated form of clotting factor VIII rapidly became the preferred treatment for acute bleeding episodes in patients with hemophilia A. This is the first successful treatment for hemophilia beyond whole blood. After cryoprecipitate is developed, life expectancy grows to 24 years old.
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