Advate



Advate

Product Specs Advate
Manufacturer Name Takeda
Description ADVATE is a recombinant antihemophilic factor indicated for use in children and adults with hemophilia A.
Indications for Adults:

Control and Prevention of Bleeding Episodes

Yes

Perioperative Management

Yes

Routine Prophylaxis to Prevent or Reduce the Frequency of Bleeding Episodes

Yes
Indications for Children:

Control and Prevention of Bleeding Episodes

Yes

Perioperative Management

Yes

Routine Prophylaxis to Prevent or Reduce the Frequency of Bleeding Episodes

Yes
Contraindications Nutrient in Cell Culture Do not use in patients who have lifethreatening hypersensitivity reactions, including anaphylaxis, to mouse or hamster protein or other constituents of the product (mannitol, trehalose, sodium chloride, histidine, Tris, calcium chloride, polysorbate 80, and/or glutathione).
Stabilizer in Final Formulation mannitol, trehalose, sodium chloride, histidine, Tris, calcium chloride, polysorbate 80, and glutathione.
Viral Safety Process Immunoaffinity chromatography; solvent/detergent
Product Half-Life 12.0 ± 4.2 hours
Product Recovery Percentage Mean incremental recovery IR (IU/dL per IU/kg) 2.6 ± 0.5
Storage Requirements
  • Refrigerated at 2°C to 8°C (36°F to 46°F), or room temperature up to 30°C (86°F).
  • Do not freeze.
  • Shelf Life 24 months from manufactured date or 6 months at room temperature
    Nominal Vial Size & Diluent Volume 2 mL, 5mL


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