ATryn

Product Specs	ATryn
Manufacturer Name	rEVO Biologics
Indications	ATryn is a recombinant antithrombin indicated for the prevention of perioperative and peripartum thromboembolic events in hereditary antithrombin deficient patients.
Contraindications	Do not use in patients with known hypersensitivity to goat and goat milk proteins.
Manufacturing Methods	Recombinant human antithrombin produced through recombinant DNA technology using genetically engineered goats. DNA sequence directs the antithrombin expression into goat’s milk.
Viral Safety Process	Tangential Flow Filtration, Affinity Chromatography, Nanofiltration Ion Exchange Chromatography, Hydrophobic Interaction Chromatography, Heat Treatment. Log10 reductions range from greater than or equal to greater than or equal to 20.0 log.
Route of Administration	May be administered intravenously via sterile syringe or via an infusion bag
Product Half-Life	50 IU/kg: 11.6 (84.7) hours 100 IU/kg: 17.7 (60.9) hours
Storage Requirements/Shelf Life	Refrigerate between 2°C and 8°C (36°F-46°F). Do not use product beyond the expiration date printed on the package.
Available Formulations	525 IU/3.2 mL 1750 IU/10 mL