Vonvendi



Vonvendi

Product Specs Vonvendi
Manufacturer Name Takeda
Indications Use in adults (age 18 and older) diagnosed with von Willebrand disease (VWD) for:

  • On-demand treatment and control of bleeding episodes
  • Perioperative management of bleeding
  • Routine prophylaxis to reduce the frequency of bleeding episodes in patients with severe Type 3 von Willebrand disease receiving on-demand therapy.
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    Contraindications Do not use in patients who have had life-threatening hypersensitivity reactions to VONVENDI or its components (mannitol, trehalose, sodium chloride, histidine, Tris, calcium chloride, polysorbate 80 and hamster or mouse proteins)
    Source Plasma Purified rVWF expressed in Chinese Hamster Ovary (CHO) cells. VONVENDI is produced and formulated without the addition of any exogenous raw materials of human or animal origin in the cell culture,purification,or formulation of the final product
    Viral Safety Process Immunoaffinity chromatography
    Product Half-Life 19.1 (4.91) hours
    Product Recovery Percentage 1.9%
    Storage Requirements
  • Refrigerated at 2°C to 8°C (36°F to 46°F) or at room temperature up to 30°C (86°F).
  • Do not return to refrigerated temperature after storing at room temperature.
  • Do not freeze.
    		•
    Shelf Life 12 months from manufactured date, at room temperature
    Nominal Vial Size & Diluent Volume 450-850 IU/5 mL
    900-1700 IU/10 mL


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